Photodermatitis

Photodermatitis is an abnormal skin response to ultraviolet (UV) rays, particularly sunlight. It can be acute or chronic. UV rays are classified by wavelength and the greater the wavelength, the greater the risk of developing photodermatitis. UVB rays range from 290 to 320 nm and may cause sunburn, tanning, aging, or cancer-causing changes to the skin. UVA rays range from 320 to 400 nm and may cause reactions to light even through window glass. Ninety percent of the UV radiation from sunlight comes from UVA rays, 10% from UVB. Photoreactions from UV rays depend upon the amount of light reaching the earth. This is influenced by the season or time of year, latitude, thickness of the ozone layer, and topography.

Photodermatitis signs and Symptoms

• Itchy bumps, blisters, or raised areas
• Lesions that resemble eczema
• Hyperpigmentation (darkened discoloration compared to one's normal skin tone)
• Outbreaks in areas of skin exposed to light
• Pain, redness, and swelling
• Chills, headache, fever, and nausea
• Less severe symptoms after repeated exposure

What Causes It?

• Tetracycline and sulfonamides, medications used for bacterial infections
• Griseofulvin, used for fungal infections
• Coal tar derivatives and psoralens, such as methoxsalen and trioxsalen, used for psoriasis
• Tretinoin and other medications containing retinoic acid used for acne
• Nonsteroidal anti-inflammatory drugs (NSAIDs), such as piroxicam
• Chemotherapy agents used to treat cancer, such as 5-fluorouracil and vinblastine
• Sulfonylureas, such as glyburide and glipizide, oral medications used for diabetes
• Quinine and other medications used to treat malaria
• Thiazide diuretics, such as hydrochlorothiazide
• Desipramine and other medications used for depression (known as tricylics)
• Phenothiazines, a class of medications used for psychosis
• Benzodiazepines, such as alprazolam and tetrazepam, medications used for anxiety disorders

• Fragrances containing, for example, musk ambrette and methylcoumarin
• Sunscreens with p-aminobenzoic acid (PABA) esters
• Industrial cleaners that contain salicylanilide

Who's Most At Risk?

• Skin type may influence the likelihood of a photodermatitis reaction. Those with fair to light skin, or those with red or blond hair, and green or blue eyes tend to be most sensitive, regardless of their racial or ethnic background. This is categorized as skin type I.
• Exposure to UV rays for 30 minutes to several hours increases risk of photodermatitis (outbreaks in spring and summer months are common)
• Exposure to UV rays from 11 a.m. to 2 p.m. also increases risk of photodermatitis since 50% of UV radiation is emitted during this time.

What to Expect at Your Provider's Office

Photodermatitis Treatment

Prevention

• Limit skin exposure to sun, especially intense midday sun.
• Use sunscreens that protect against UVA and have a sun protection factor (SPF) of 30 to 50.
• Cover up with a long-sleeved shirt, long pants, and a wide-brimmed hat.
• Beware of using any product that causes sun sensitivity. (If you are already taking a prescription medication, however, do not stop taking it without consulting your healthcare provider.)

Treatment Plan

Drug Therapies

Complementary and Alternative Therapies

• Beta-carotene and Other Carotenoids: Despite the fact that beta-carotene is considered part of standard treatment for photodermatitis, the results of studies regarding this supplement have been mixed. One study of the effect of beta-carotene supplements on sunburns in humans showed no significant protection. In another trial, though, 20 healthy subjects received either carotenoids alone, mainly from beta-carotene, or carotenoids plus vitamin E. Both groups improved significantly. Vitamin E did not appear to add to the benefits of the carotenoids alone.
• Fish Oil/Omega-3 Fatty Acids: In one study, 13 patients with a particular type of photodermatitis received supplements of fish oil, which contains omega-3 fatty acids, for three months. Tests afterward showed that the patients were significantly less sensitive to UV rays. Similarly, case reports of three children with hydroa vacciniforme, a rare scarring photosensitivity disorder, found that omega-3 supplements lessened symptoms for two of the three children. Photosensitive patients could consider eating a diet rich in omega-3 fatty acids, such as from cold water fish.
• Protein: Actinic prurigo, a form of photosensitivity marked by ongoing outbreaks of itchy bumps during hot weather, is seen mainly in malnourished individuals. Research suggests that the condition is related to a diet deficient in protein or a specific amino acid (the building blocks of protein). Patients treated with a high-protein diet have improved but tend to relapse a few weeks after returning to their standard diet.
• Vitamin B3: Nicotinamide (a form of niacin, or vitamin B3) may make a photosensitive reaction less likely. In a pilot study, 42 people with photodermatitis were given nicotinamide; despite extensive sun exposure, 25 of these people did not develop lesions.
• Vitamins C and E: Antioxidants, including vitamins C and E, help remove free radicals, harmful by-products that result from cells' use and generation of energy. Free radicals are linked to skin damage. Oral supplements of vitamins C and E seem to work together to possibly reduce UV-induced skin reactions.
• Vitamin D: In animal studies, vitamin D helped trigger the effects of an antioxidant protein found in skin cells of rats. This protein helps to protect against damage from UVB rays. It is not clear yet whether vitamin D supplements may help protect humans in the same way.

• Green Tea: The antioxidant properties in green tea (Camellia sinensis) may provide protection against reddening of the skin caused by UV light. Epigallocatechin-3-gallate (EGCG), an active component of green tea has demonstrated photoprotection in animal studies. In a human study, tests on skin samples showed that EGCG does not block the absorption of UVB light but it does appear to inhibit redness, some cell damage, and other changes normally associated with UVB rays.
• Calendula: Although not studied scientifically, this herb has been used clinically for skin conditions including sunburn. It may also be used as a homeopathic remedy at doses consistent with that kind of therapy.

Prognosis/Possible Complications

• Ongoing photosensitivity, resulting in chronic photodermatitis
• Hyperpigmentation or dark discoloration compared to normal skin tone even after inflammation has resolved
• Premature aging of the skin
• Squamous cell or basal cell skin cancer or melanoma

Following Up